Disease landscape
Multiple Sclerosis
Moderate restrictions in access to multiple sclerosis treatment and diagnosis have been identified in the Visegrád (V4) countries as measured in the GAP score. Results vary markedly from country to country and the difference between the highest and the lowest scoring country is over 26 points. The main reason for the relatively unfavourable assessment is zero to ultra low percentage of patients treated with sphingosine 1-phosphate receptor modulators in all the V4 countries.
Cross-Country
General GAP for Multiple Sclerosis
Compliance with guidelines
Positive recommendations for 7 multiple sclerosis drugs were found in clinical practice guidelines. All of them are available to multiple sclerosis patients in every V4 country. This is however due to the obsolescence of the guidelines rather than the impressive performance of the V4 region.
From registration to reimbursement
Population burden
DALY* - Rate per 100k
*disability adjusted life-years
Target population
Sphingosine 1-phosphate receptor modulator
Drug access
Number of patientS treated
Drug access
Population treated (%)
Main issues
- The average time to reimbursement for multiple sclerosis drugs in the V4 countries is more than 2.1 years. The difference between the shortest and the longest mean time to reimbursement among the countries is 1.0 year.
- Sphingosine 1-phosphate receptor modulators’ reimbursement was only implemented in 2021-2022 in V4 states and thus the percentage of target population treated with those drugs was very low: 0%-2% in all V4 countries.
- Population burden in V4 states is much lower than the European Union average. A decreasing trend or stabilization of DALY values was observed in V4 states in past years.
Project
We measured the gap in innovative drug access and diagnostics in selected therapeutic areas in the Visegrád (V4) countries (Poland, Hungary, Czechia and Slovakia).